Phototoxicity results from light-activated chemicals upon exposure to UV or visible light, impacting skin through photo irritation, photo allergy, and photo genotoxicity. Evaluation, crucial for cosmetics and drugs, includes the Phototoxicity Test assessing cytotoxic effects. Despite criticisms, it is generally robust, with suggestions to enhance realism by using human keratinocytes. 3D human skin models offer flexibility for studying phototoxicity, incorporating in vivo parameters. The OECD guideline focuses on assessing the phototoxic potential of chemicals on reconstructed human epidermis (RhE) tissues under simulated sunlight. No Integrated Approaches to Testing and Assessment (IATA) developments are noted, but combining fibroblast and RhE models into an IATA is a potential consideration, along with integrating genotoxicity or skin sensitization assays for enhanced evaluation.