Genetic Toxicology

Genotoxicity services for comprehensive evaluations

"Vipragen offers an extensive array of Genotoxicity studies, encompassing both in vitro and in vivo assessments to identify potential mutagenic, clastogenic and aneugenic compounds capable of causing DNA damage, chromosomal structural changes and disruptions in the mitotic apparatus, and variations in chromosome number, respectively.

Vipragen's Genotoxicity services include validated tests and their respective methodologies and deliverables such as:"

Bacterial Reverse Mutation (AMES) Test, OECD 471, ICH S2R1

In Vitro Mammalian Chromosomal Aberration Test (OECD 473, ICH S2R1 )

In Vivo Chromosomal Aberration Test (OECD 475, ICH S2R1 tests )

In Vivo Mouse Erythrocytes Micronucleus Test (OECD 474, ICH S2R1)

In Vitro Micronucleus (OECD 487, ICH S2R1) Tests )

Local Lymph Node Assay (OECD 442 B)

Mouse Lymphoma Assay (OECD 490)

Cell Gene Mutation Test (OECD 476)

In vitro Skin Irritation Test (OECD 439)

In vitro Skin Corrosion Test (OECD 431)

In vitro Eye Irritation Test (OECD 492)

Mammalian Alkaline Comet Assay (OECD 489)

Modified Ames Testing (ASTME 1687)